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CART T Elicits Sturdy Response for A number of Myeloma


Dec. 9, 2020 — For sufferers with heavily-pretreated a number of myeloma, the robust responses seen with the brand new (CAR T-cell therapy ciltacabtagene autoleucel (cilta-cel) have additionally been extended, in keeping with investigators within the CARTITUDE-1 trial.

Amongst 97 sufferers with a number of myeloma whose most cancers acquired worse whereas on three or extra prior sorts of therapy or following therapy with at the very least two sorts of remedy with a proteasome inhibitor and immunomodulating agent, the general response fee was 96.9%, reported Deepu Madduri, MD, of Mount Sinai Medical Heart in New York, and colleagues.

“We noticed how closely pretreated these sufferers had been, and to see a one-time therapy get these form of response charges is sort of distinctive. What’s much more spectacular is that 72% of those sufferers had been nonetheless sustaining their response on the time of information cutoff,” she mentioned in an oral summary offered throughout the digital American Society of Hematology annual assembly.

Cilta-cel is a second-generation CAR T.

It was granted a breakthrough remedy designation for relapsed/refractory a number of myeloma by the FDA in December 2019.

On the 2019 ASH annual assembly, Madduri reported part 1b outcomes from the trial, which confirmed that for 29 sufferers with closely pretreated, relapsed/refractory a number of myeloma, the general response fee at 6 months median follow-up was 100%, together with 69% who had no indicators of most cancers, with 27 sufferers remaining freed from illness development.


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All sufferers had at the very least one hematologic facet impact, 96 of which had been extra extreme. The occasions embody neutropenia, anemia, thrombocytopenia, leukopenia, and lymphopenia. The median time to restoration was 2 to 4 weeks.

Infections occurred in 57.7% of sufferers, together with pneumonia in 8.2% and sepsis in 4.1%.

Cytokine launch syndrome of any kind occurred in 92 sufferers, however solely 4 had a extra extreme case.

Neurotoxicities occurred in 20 sufferers, of whom 10 had extra extreme instances.

Immune effector cell-associated neurotoxicity syndrome (ICANS) occurred in 16 sufferers, with 2 having extra extreme instances. The syndrome impacts the central nervous system. Different neurotoxicities of any severity, many which overlapped with ICANS, occurred in 12 sufferers, with 9 extra extreme.

The median time to ICANS onset was 8 days, with a median time to restoration of 4 days. Different neurotoxicities took longer to manifest and disappear, nonetheless, with a median time to onset of 27 days, and median time to restoration of 75 days.


The research was sponsored by Janssen Analysis & Growth and Legend Biotech. Madduri disclosed honoraria, consultancy, and audio system bureau actions for these corporations and others.



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