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CDC Panel: No COVID-19 Vaccine Security Surprises


Jan. 27, 2021 — The U.S. is almost 6 weeks into its historic marketing campaign to vaccinate Individuals towards the virus that causes COVID-19, and up to now, the 2 vaccines in use look remarkably low-risk, in line with new knowledge offered right this moment at a gathering of vaccine specialists that advise the CDC.

With 23.5 million doses of the Pfizer and Moderna vaccines now given, there have been only a few critical uncomfortable side effects. As well as, deaths reported after folks acquired the vaccine don’t appear to be associated to it.



The most typical signs reported after vaccination have been ache the place folks acquired the shot, fatigue, headache, and muscle soreness. These have been extra frequent after the second dose. As well as, about 1 in 4 folks reported fever and chills after the second shot.

“On the entire, I assumed it was very reassuring,” mentioned William Schaffner, MD, an infectious illness skilled with Vanderbilt College Faculty of Drugs in Nashville who listened to the displays.

The CDC is accumulating security data by a number of channels. These embody a brand new smartphone-based app known as V-Secure, which collects every day data from individuals who’ve been vaccinated; the federal Vaccine Opposed Occasion Reporting System, or VAERS, which accepts studies from anybody; and the Vaccine Security Datalink, which is a collaboration between the CDC and 9 main hospital techniques. There’s additionally CISA, the Medical Immunization Security Evaluation Challenge, a collaboration between the CDC and vaccine security specialists.

After surveying these techniques, specialists heading the security committee for the CDC’s Advisory Committee on Immunization Practices say there have been few critical uncomfortable side effects reported.

Very hardly ever, extreme allergic reactions — known as anaphylaxis — have occurred after vaccination. There have been 50 of those circumstances reported after the Pfizer vaccine and 21 circumstances reported after the Moderna vaccine to this point. Practically all of them — 94% of the anaphylaxis circumstances after Pfizer vaccines and 100% of these after Moderna’s vaccine — have been in girls, although it’s not clear why.

That interprets to a charge of about 5 circumstances of anaphylaxis for each million doses of the Pfizer vaccine and about three for each million doses of the Moderna vaccine. Most of those happen inside quarter-hour after getting a vaccine dose, with one reported so long as 20 hours after the shot.

The CDC suspects these could also be associated to an ingredient known as polyethylene glycol, or PEG. PEG is part of the particles that slip the vaccines’ mRNA into cells with directions to make the spike protein of the virus. Cells then specific these spikes on their surfaces so the immune system can study to acknowledge them and make defenses towards them. PEG is a typical ingredient in lots of medicine and infrequently triggers anaphylaxis.



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